| Series |
Advances in experimental medicine and biology, 2214-8019 ; volume 1091 |
|
Advances in experimental medicine and biology ;
v. 1091.
0065-2598
|
| Subject |
Aluminum -- Toxicology.
|
|
Aluminum -- Physiological effect.
|
|
Neurotoxicology.
|
|
Aluminum -- toxicity.
|
|
Nervous System Diseases -- chemically induced.
|
|
Aluminum -- metabolism.
|
|
Cognition -- drug effects.
|
|
Alzheimer Disease -- chemically induced.
|
|
Environmental Exposure.
|
| Alt Name |
Niu, Qiao,
|
| Description |
1 online resource (vii, 191 pages) : illustrations (some color). |
| Bibliography Note |
Includes bibliographical references. |
| Contents |
Overview of the relationship between aluminum exposure and health of human being / Qiao Niu -- The chemistry of human exposure to aluminium / Christopher Exley -- Entry and deposit of aluminum in the brain / Linping Wang -- Aluminum as a CNS and immune system toxin across the life span / Christopher A. Shaw -- Occupational exposure to aluminum and cognitive impairment / Xiaoting Lu -- Exposure to aluminum in daily life and Alzheimer's disease / Jisheng Nie -- Animal model of aluminum-induced Alzheimer's disease / Jing Song -- Aluminum-induced neural cell death / Qinli Zhang -- Aluminum-induced electrophysiological variation, synaptic plasticity impairment, and related mechanism / Huifang Zhang -- Cross talk between aluminum and genetic susceptibility and epigenetic modification in Alzheimer's disease / Ruifeng Liang. |
| Summary |
"This book reviews the scientific literature and the authors' own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer's disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum's complex speciation chemistry in relation to biology, and details aluminum's mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal's debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity"--Publisher's description. |
| Note |
Description based on online resource; title from electronic title page (SpringerLink, viewed October 16, 2018). |
| ISBN |
9789811313707 (electronic bk.) |
|
9811313709 (electronic bk.) |
|
9789811313691 hardcover : alk. paper |
|
9811313695 hardcover : alk. paper |
| ISBN/ISSN |
10.1007/978-981-13-1370-7 |
| OCLC # |
1057018552 |
| Additional Format |
Print version: Neurotoxicity of aluminum. Singapore : Springer, [2018] 9789811313691 (DLC) 2018955290 (OCoLC)1038452629 |
|
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