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LEADER 00000cam  2200637Ii 4500 
001    1078636561 
003    OCoLC 
005    20191108044103.9 
006    m     o  d         
007    cr cnu---unuuu 
008    181210s2018    si      ob    000 0 eng d 
015    GBB953306|2bnb 
019    1078881850|a1079832833|a1083985419|a1122811358 
020    9789811319129|q(electronic bk.) 
020    981131912X|q(electronic bk.) 
020    |z9789811319112 
020    |z9811319111 
024 7  10.1007/978-981-13-1912-9|2doi 
035    (OCoLC)1078636561|z(OCoLC)1078881850|z(OCoLC)1079832833
037    com.springer.onix.9789811319129|bSpringer Nature 
040    N$T|beng|erda|epn|cN$T|dN$T|dEBLCP|dGW5XE|dYDX|dDKU|dUAB
049    MAIN 
050  4 QP625.O47 
072  7 TDC|2thema 
072  7 TDCW|2bicssc 
072  7 SCI|x007000|2bisacsh 
082 04 572.85|223 
245 00 Synthesis of therapeutic oligonucleotides /|cSatoshi Obika,
       Mitsuo Sekine, editors. 
264  1 Singapore :|bSpringer,|c2018. 
300    1 online resource 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0
347    text file|bPDF|2rda 
504    Includes bibliographical references. 
505 0  Intro; Preface; Contents; Part I: Synthesis of Natural 
       Oligonucleotides; Non-protected Synthesis 
       ofOligonucleotides; 1 Introduction; 2 Development ofProton
       -Block Strategy fortheSynthesis ofOligonucleotides 
       WithoutBase Protection; 3 Development oftheActivated 
       Phosphite Method Using N-Unprotected Phosphoramidites; 4 
       Mechanism oftheActivated Phosphite Method; 5 Synthesis 
       ofRNA Oligomers Using theActivated Phosphite Method; 6 
       Synthesis ofPhosphoramidite Monomer Building Blocks; 7 
       Conclusion; References 
505 8  Various Coupling Agents inthePhosphoramidite Method 
       forOligonucleotide Synthesis1 Introduction; 2 Coupling 
       Agents inthePhosphoramidite Method; 2.1 1H-Tetrazole 
       andIts Derivatives; 2.1.1 1H-Tetrazole; 2.1.2 5-Ethylthio-
       1H-tetrazole; 2.1.3 5-Benzylthio-1H-tetrazole; 2.1.4 5-[3,
       5-Bis(trifluoromethyl)phenyl]-1H-tetrazole (Activator 42);
       2.2 4,5-Dicyanoimidazole; 2.3 Carboxylic Acids; 2.4 Acid/
       Azole Complexes; 3 Conclusion; References; Recent 
       Development ofChemical Synthesis ofRNA; 1 Introduction; 2 
       Basic Principle ofSolid-Phase Synthesis ofDNA/RNA 
       inPhosphoramidite Approach 
505 8  3 Current RNA Synthesis Using TBDMS as2′-Hydroxyl 
       Protecting Group4 RNA Synthesis Using Acid-Labile 2&
       #x2032;-Hydroxyl Protecting Groups; 5 RNA Synthesis Using 
       2′-Protecting Groups Having anAcetal Skeleton; 5.1 
       (2-Nitrobenzyl)oxymethyl (NBOM) Group; 5.2 2-
       (Trimethylsilyl)ethoxymethyl (SEM) Group; 6 RNA Synthesis 
       Using theTriisopropylsilyloxymethyl (Tom) Group; 7 
       Cyanoethoxy-1-Methylethyl (CEE) andCyanoethoxymethyl (CEM)
       Groups; 8 RNA Synthesis Using 4-
       Methylphenylsulfonylethoxymethyl (TEM) Group; 9 RNA 
       Synthesis Using tert-Butyldithiomethyl (DTM) Group 
505 8  10 RNA Synthesis Using [[2-(Methylthio)phenyl]thio]methyl 
       (MPTM) Group11 RNA Synthesis Using (N-Dichloroacetyl-N-
       methyl)aminobenzyloxylmethyl (DCMABOM) Group; 12 RNA 
       Synthesis Using theAcetal Levulinyl Ester (ALE) Group; 13 
       RNA Synthesis Using theCyanoethyl (CE) Group; 14 RNA 
       Synthesis Without Using Base Protection; 15 Recent Studies
       onRNA Chemical Synthesis; 16 Summary andPerspectives; 
       References; RNA Synthesis Using theCEM Group; 1 
       Introduction; 2 Synthesis ofCEM Amidites; 3 Synthesis 
       ofRNA; 4 Experimental Section; 4.1 Preparation ofCEM-SMe 
505 8  4.2 Synthesis ofU-CEM Phosphoramidite (5a.)4.2.1 32 52 O-
       (Tetraisopropyldisiloxane-1,3-diyl)-22 O-(2-
       cyanoethoxymethyl)uridine (2a.); 4.2.2 22 O-(2-
       Cyanoethoxymethyl)uridine (3a.); 4.2.3 52 O-(4,42 
       Dimethoxytrityl)-22 O-(2-xyanoethoxymethyl)uridine (4a.); 
       4.2.4 52 O-(4,42 Dimethoxytrityl)-22 O-(2-
       cyanoethoxymethyl)uridine 32 O-(2-Cyanoethyl N, N-
       diisopropylphosphoramidite) (5a.); 4.3 Synthesis ofC-CEM 
       Phosphoramidite (5b.); 4.3.1 4-N-Acetyl-32 52 O-
       (tetraisopropyldisiloxane-1,3-diyl)-22 O-(2-
       cyanoethoxymethyl)cytidine (2b.); 4.3.2 4-N-Acetyl-22 O-(2
       -cyanoethoxymethyl)cytidine (3b.) 
520    This book presents the latest knowledge on a broad range 
       of topics relating to the synthesis of natural and 
       artificial oligonucleotides with therapeutic potential. 
       Nucleic acid-based therapeutics are attracting much 
       attention, and numerous therapeutic oligonucleotides, such
       as antisense oligonucleotides, siRNAs, splice-switching 
       oligonucleotides, and nucleic acid aptamers, are being 
       evaluated in clinical trials for the treatment of a 
       variety of diseases. Synthesis of Therapeutic 
       Oligonucleotides covers a broad range of topics in the 
       field that are of high relevance to researchers, including
       the synthesis of natural and chemically modified 
       oligonucleotides, the development of novel nucleic acid 
       analogs, industrial scale synthesis and purification of 
       oligonucleotides, and important aspects of chemistry, 
       manufacturing, and controls (CMC). The aim is to provide 
       new insights and inspire fresh ideas in nucleic acid 
       chemistry that may ultimately lead to novel concepts and 
       techniques and the discovery of more effective nucleic 
       acid drugs. The book will be of high value for both 
       established researchers in the field and students 
       intending to specialize in nucleic acid chemistry 
588 0  Online resource; title from PDF title page (EBSCO, viewed 
       December 11, 2018) 
650  0 Oligonucleotides.|0
700 1  Obika, Satoshi,|0
700 1  Sekine, Mitsuo,|d1949-|0
776 08 |iPrint version:|tSynthesis of therapeutic 
       oligonucleotides.|dSingapore : Springer, 2018|z9811319111
990    SpringerLink|bSpringer English/International eBooks 2018 -
       Full Set|c2019-11-08|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2018 -
       Full Set|c2019-11-01|yMaster record variable field(s) 
       change: 505|5OH1 
990    SpringerLink|bSpringer English/International eBooks 2018 -
       Full Set|c2019-01-11|yAdded to collection 
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