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EBOOK
Title Modulation of protein stability in cancer therapy / Kathleen Sakamoto, Eric Rubin, editors.
Imprint New York : Springer-Verlag, 2009.

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Subject Cancer -- Treatment.
Protein drugs.
Ubiquitin -- physiology.
Proteins -- therapeutic use.
Protease Inhibitors -- therapeutic use.
Neoplasms -- therapy.
Ubiquitins -- physiology.
Alt Name Sakamoto, Kathleen.
Rubin, Eric.
Description 1 online resource
polychrome rdacc http://rdaregistry.info/termList/RDAColourContent/1003
Bibliography Note Includes bibliographical references and index.
Contents Ubiquitin Ligases and Cancer -- The 26S Proteasome as a Therapeutic Target in Cancer: Beyond Protease Inhibitors? -- Targeting HAUSP: Killing Two Birds with One Stone -- Modulation of Protein Stability: Targeting the VHL Pathway -- Interrelationship of the Fanconi Anemia/BRCA Pathway -- Targeting the Sumoylation Pathway -- Proteasome Inhibitors -- Targeting Deubiquitinating Enzymes -- Proteolysis Targeting Chimeric Molecules.
Summary This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.
Access Licensed electronic resource available to Carleton faculty, staff and students.
Note Print version record.
ISBN 9780387691473
0387691472
9780387691435
038769143X
OCLC # 405547786
Additional Format Print version: Modulation of protein stability in cancer therapy. New York : Springer-Verlag, 2009 9780387691435


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