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EBOOK
Title Percutaneous absorption : drugs--cosmetics--mechanisms--methodology / edited by Robert L. Bronaugh, Howard I. Maibach.
Imprint New York : Dekker, 1999.
Edition 3rd ed., rev. and expanded.

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Series Drugs and the pharmaceutical sciences ; 97
Drugs and the pharmaceutical sciences ; v. 97.
Subject Transdermal medication.
Skin absorption.
Skin -- Permeability.
Skin Absorption.
Alt Name Bronaugh, Robert L., 1942-
Maibach, Howard I.
Description 1 online resource (xxi, 955 pages) : illustrations.
Edition 3rd ed., rev. and expanded.
Bibliography Note Includes bibliographical references and index.
Contents Mechanisms of absorption -- Methodology -- Drug and cosmetic absorption.
Summary Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines. An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel. -- Provided by publisher.
Note Print version record.
ISBN 0585138680 (electronic bk.)
9780585138688 (electronic bk.)
0824719662 (alk. paper)
OCLC # 44958498
Additional Format Print version: Percutaneous absorption. 3rd ed., rev. and expanded. New York : Dekker, 1999 0824719662 (DLC) 99014994 (OCoLC)41096075
Table of Contents
 Preface to the Third Edition 
 Preface to the First Edition 
 Contributors 
IMechanisms of Absorption 
 1Mathematical Models in Percutaneous Absorption / Michael S. Roberts, Yuri G. Anissimov, Richard A. Gonsalvez3
 2Cutaneous Metabolism During In Vitro Percutaneous Absorption [et al.] / Robert L. Bronaugh, Margaret E. K. Kraeling, Jeffrey J. Yourick57
 3Cutaneous Metabolism of Xenobiotics / Saqib J. Bashir, Howard I. Maibach65
 4Occlusion Does Not Uniformly Enhance Penetration In Vivo / Daniel Bucks, Howard I. Maibach81
 5Regional Variation in Percutaneous Absorption / Ronald C. Wester, Howard I. Maibach107
 6In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss / Andre Rougier, Claire Lotte, Howard I. Maibach117
 7Skin Contamination and Absorption of Chemicals from Water and Soil / Ronald C. Wester, Howard I. Maibach133
 8Characterization of Molecular Transport Across Human Stratum Corneum In Vivo [et al.] / Aarti Naik, Yogeshvar N. Kalia, Fabrice Pirot149
 9Relationship Between H-Bonding of Penetrants to Stratum Corneum Lipids and Diffusion / William John Pugh177
 10In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/Vehicle Partitioning / Andre Rougier193
IIMethodology 
 11In Vivo Methods for Percutaneous Absorption Measurements / Ronald C. Wester, Howard I. Maibach215
 12Determination of Percutaneous Absorption by In Vitro Techniques [et al.] / Robert L. Bronaugh, Harolyn L. Hood, Margaret E. K. Kraeling229
 13Will Cutaneous Levels of Absorbed Material Be Systemically Absorbed? / Robert L. Bronaugh, Harolyn L. Hood235
 14Dermal Decontamination and Percutaneous Absorption / Ronald C. Wester, Howard I. Maibach241
 15Partitioning of Chemicals from Water into Powdered Human Stratum Corneum (Callus) - A Model Study [et al.] / Xiaoying Hui, Ronald C. Wester, Philip S. Magee255
 16In Vitro Percutaneous Absorption of Model Compounds Glyphosate and Malathion from Cotton Fabric into and Through Human Skin / Ronald C. Wester, Danyi Quan, Howard I. Maibach271
 17Vaginal Absorption of Prostaglandin E[subscript 1] in Rhesus Monkey [et al.] / Ronald C. Wester, Joseph L. Melendres, Steffany Serranzana283
 18Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Effects of Heat Separation and Freezing [et al.] / Ronald C. Wester, Julie Christoffel, Tracy Hartway289
 19Interrelationships in the Dose Response of Percutaneous Absorption / Ronald C. Wester, Howard I. Maibach297
 20Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques / Ethel Tur315
 21Drug Concentration in the Skin [et al.] / Christian Surber, Eric W. Smith, Fabian P. Schwarb347
 22Stripping Method for Measuring Percutaneous Absorption In Vivo [et al.] / Andre Rougier, Didier Dupuis, Claire Lotte375
 23Tape-Stripping Technique / Christian Surber, Fabian P. Schwarb, Eric W. Smith395
 24Interference with Stratum Corneum Lipid Biogenesis: An Approach to Enhance Transdermal Drug Delivery [et al.] / Peter M. Elias, Vivien Mak, Carl Thornfeldt411
 25Percutaneous Drug Delivery to the Hair Follicle / Andrea C. Lauer427
 26Relative Contributions of Human Skin Layers to Partitioning of Chemicals with Varying Lipophilicity [et al.] / Tatiana E. Gogoleva, John I. Ademola, Ronald C. Wester451
 27Effect of Single Versus Multiple Dosing in Percutaneous Absorption / Ronald C. Wester, Howard I. Maibach463
 28Measurement of Short-Term Dermal Uptake In Vitro Using Accelerator Mass Spectrometry / Garrett A. Keating, Kenneth T. Bogen, John S. Vogel475
 29New Developments in the Methodology Available for the Assessment of Topical Corticosteroid-Induced Skin Blanching / John M. Haigh, Eric W. Smith, Howard I. Maibach487
 30Raman Spectroscopy / Adrian C. Williams, Brian W. Barry499
 31Stratum Corneum and Barrier Performance: A Model Lamellar Structural Approach / Hamid R. Moghimi, Brian W. Barry, Adrian C. Williams515
 32Role of In Vitro Release Measurement in Semisolid Dosage Forms / Vinod P. Shah, Jerome S. Elkins, Roger L. Williams555
 33Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, and p-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Humans In Vivo [et al.] / Ronald C. Wester, Joseph L. Melendres, Lena Sedik571
 34Transepidermal Water Loss Measurements for Assessing Skin Barrier Functions During In Vitro Percutaneous Absorption Studies / Avinash Nangia, Bret Berner, Howard I. Maibach587
IIIDrug and Cosmetic Absorption 
 35Percutaneous Penetration as a Method of Delivery to Skin and Underlying Tissues / Parminder Singh597
 36Phonophoresis / Joseph Kost, Samir Mitragotri, Robert Langer615
 37Facilitated Transdermal Delivery by Iontophoresis / Parminder Singh, Puchun Liu, Steven M. Dinh633
 38Percutaneous Penetration as It Relates to the Safety Evaluation of Cosmetic Ingredients / Jeffrey J. Yourick, Robert L. Bronaugh659
 39Percutaneous Absorption of Fragrances / Jeffrey J. Yourick, Harolyn L. Hood, Robert L. Bronaugh673
 40Hair Dye Absorption / William E. Dressler685
 41Percutaneous Absorption of Alpha-Hydroxy Acids in Human Skin / Margaret E. K. Kraeling, Robert L. Bronaugh717
 42Optimizing Patch Test Delivery: A Model / Ronald C. Wester, Howard I. Maibach733
 43Permeation of N-Nitrosamines Through Human Skin / Keith R. Brain, Stephen D. Gettings, Kenneth A. Walters741
 44Nail Penetration: Focus on Topical Delivery of Antifungal Drugs for Onychomycosis Treatment [et al.] / Ying Sun, Jue-Chen Liu, Jonas C. T. Wang759
 45Topical Dermatological Vehicles: A Holistic Approach / Eric W. Smith, Christian Surber, Howard I. Maibach779
 46Human In Vivo and In Vitro Hydroquinone Topical Bioavailability, Metabolism, and Disposition [et al.] / Ronald C. Wester, Joseph L. Melendres, Xiaoying Hui789
 47Human Skin In Vitro Percutaneous Absorption of Gaseous Ethylene Oxide from Fabric [et al.] / Ronald C. Wester, Tracy Hartway, Steffany Serranzana809
 48In Vivo Percutaneous Absorption of Acetochlor in Rhesus Monkey: Dose Response and Exposure Risk Assessment / Ronald C. Wester, Joseph L. Melendres, Howard I. Maibach815
 49The Development of Skin Barrier Function in the Neonate [et al.] / Lourdes B. Nonato, Yogeshvar N. Kalia, Aarti Naik825
 50Percutaneous Absorption of Sunscreens / Kenneth A. Walters, Stephen D. Gettings, Michael S. Roberts861
 51Microemulsions / Reinhard H. H. Neubert, Ulrike Schmalfuss879
 52Bioavailability of [[superscript 14]C]Hydroquinone in F344 Rat and Rhesus Monkey [et al.] / Xiaoying Hui, Ronald C. Wester, Joseph L. Melendres887
 53Dermatopharmacokinetics of Topical BCX-34 Cream in Human Skin [et al.] / Xiaoying Hui, Ronald C. Wester, Steffany Serranzana901
 54In Vitro Cutaneous Disposition of a Topical Diclofenac Lotion in Human Skin: Effect of a Multidose Regimen [et al.] / Philip G. Hewitt, Nicholas Poblete, Ronald C. Wester915
 55An Innovative Method to Determine Percutaneous Absorption: Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling / Karla D. Thrall, Torka S. Poet, Richard A. Corley929
 56Role of Calcium Ions in Relation to Skin Barrier Function / Hanafi Tanojo, Howard I. Maibach939
 Index951



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