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EBOOK
Title Structure-based drug design / edited by Pandi Veerapandian.
Imprint New York : Marcel Dekker, [1997]
©1997

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Subject Drugs -- Design.
Drugs -- Structure-activity relationships.
Drugs -- Conformation.
Drug Design.
Structure-Activity Relationship.
Alt Name Veerapandian, Pandi.
NetLibrary, Inc.
Description xiii, 647 pages : illustrations ; 24 cm
polychrome rdacc http://rdaregistry.info/termList/RDAColourContent/1003
Bibliography Note Includes bibliographical references (p. 620-634) and index.
Reproduction Electronic reproduction. Boulder, Colo. : NetLibrary, 2000. Available via the World Wide Web. Available in multiple electronic file formats. Access may be limited to NetLibrary affiliated libraries.
ISBN 0585157448 (electronic bk.) : $195.00
0824798694 (hardcover : alk. paper)
OCLC # 44954983
Additional Format Original (DLC) 97020396 (OCoLC)36884865.
Table of Contents
 Preface 
 Contributors 
1Inhibitors of HIV-1 Protease / Krzysztof Appelt1
2Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design / Jianping Ding, Kalyan Das, Prem N. S. Yadav [et al.]41
3Retroviral Integrase: Structure as a Foundation for Drug Design / Alison B. Hickman, Fred Dyda83
4Bradykinin Receptor Antagonists / Donald J. Kyle119
5Design of Purine Nucleoside Phosphorylase Inhibitors / Y. Sudhakara Babu, John A. Montgomery, Charles E. Bugg [et al.]151
6Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors / John C. Spurlino171
7Structure-Function Relationships in Hydroxysteroid Dehydrogenases / Igor Tsigelny, Michael E. Baker191
8Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling / Janusz M. Sowadski, Charles A. Ellis, Rolf Karlsson [et al.]213
9Structural Studies of Aldose Reductase Inhibition / David K. Wilson, J. Mark Petrash, Florante A. Quiocho229
10Structure-Based Design of Thrombin Inhibitors / Patricia C. Weber, Michael Czarniecki247
11Design of Antithrombotic Agents Directed at Factor Xa / William C. Ripka265
12Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants / Raymond S. Norton295
13Rational Design of Renin Inhibitors / V. Dhanaraj, J. B. Cooper321
14Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase / Jukka Vidgren, Martti Ovaska343
15Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes / Christopher L. M. J. Verlinde, Hidong Kim, Bradley E. Bernstein [et al.]365
16Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1 / Glen Spraggon, Pandi Veerapandian395
17Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design / Michael A. Jarpe, Carol H. Pontzer, Brian E. Szente [et al.]435
18The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase / Joseph N. Varghese459
19Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design / Vincent L. Giranda, Guy D. Diana487
20The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery / Roger Bone, F. Raymond Salemme525
21Structure-Based Combinatorial Ligand Design / Amedeo Caflisch, Claus Ehrhardt541
22Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design / Tomi K. Sawyer559
 Index635


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