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Title Inflammatory cells and mediators in CNS diseases / edited by Robert R. Ruffolo, Jr. [and others].
Imprint Amsterdam : Harwood Academic Publishers, [1999]

Series New horizons in therapeutics, 1027-6580
New horizons in therapeutics. 1027-6580
Subject Central nervous system -- Diseases.
Central Nervous System Diseases -- physiopathology.
Central Nervous System Diseases -- therapy.
Inflammation Mediators.
Inflammation -- physiopathology.
Genre/Form Electronic books.
Electronic book.
Conference papers and proceedings.
Alt Name Ruffolo, Robert R.
SmithKline Beecham Pharmaceuticals United States Research Symposium (9th : King of Prussia, Pa.)
Description 1 online resource (xxii, 518 pages) : illustrations (some color).
polychrome rdacc
Bibliography Note Includes bibliographical references and index.
Contents Book Cover; Title; Contents; Preface to the Series; Preface to the Volume; Contributors; Perspectives in Neuroinjury and Disease; Unique Aspects of Inflammation in the Central Nervous System; Parenchymal Cell Death and Leukocyte; Endothelial Cell Interaction in Acute Experimental Inflammation; Apoptosis in Neurodegenerative Diseases: New Therapeutic Opportunities; Constitutive Nitric Oxide Synthase and Ischemic/Excitotoxic Brain Injury; Osteopontin in Oxidative Stress Responses; Inducible Nitric Oxide Synthase Gene Expression and Ischemic Brain Damage.
chapter 1 Perspectives in Neuroinjury and Disease / ANDREW A. PARSONS* and A. JACQUELINE HUNTER -- chapter 2 Unique Aspects of Inflammation in the Central Nervous System / V. HUGH PERRY*, M.D. BELL and D.C. ANTHONY -- chapter 3 Parenchymal Cell Death and Leukocyte-Endothelial Cell Interaction in Acute Experimental Inflammation / GEERT W. SCHMID-SCHÖNBEIN*, -- chapter 4 Apoptosis in Neurodegenerative Diseases: New Therapeutic Opportunities / MATTHEW D. LINNIK -- chapter 5 Constitutive Nitric Oxide Synthase and Ischemic/Excitotoxic Brain Injury / TURGAY DALKARA -- chapter 6 Osteopontin in Oxidative Stress Responses / GEORG F. WEBER -- chapter 7 Inducible Nitric Oxide Synthase Gene Expression and Ischemic Brain Damage / COSTANTING IADECOLA -- chapter 8 Inflammatory Factors Regulating the Blood-brain Barrier / W. DALTON DIETRICEH* -- chapter 9 The Role of Superoxide Radicals in the Pathogenesis of Cerebral Ischemic Cell Death / Pak H. Chan -- chapter Cytokine Expresssion in Brain Tumors: Its Role in Tumor Biology and Tumor-associated Immune Responses / ERWIN G. VAN MEIR* -- chapter The Inflammatory Mediator Platelet-Activating Factor and the Inducible Prostaglandin Synthase (COX-2) Gene in CNS Diseases -- chapter 12 Cytokines and Matrix Metalloproteinases in Inflammation of the Blood-Brain Barrier / GARY A. ROSENBERG -- chapter 13 Stroke Studies with Anti-Inflammatory Agents / WAYNE M. CLARK -- chapter Complement in Brain Inflammation and Injury / B. PAUL MORGAN* -- chapter 15 Gene Expression in Stroke / GIORA FEUERSTEIN -- chapter 16 Leukocyte Adhesion Molecules in the Treatment of Stroke / MICHAEL CHOPP* and ZHENG GANG ZHANG -- chapter 17 Tumor Necrosis Factor α in Stroke and Neurotrauma / FRANK C. BARONE -- chapter 18 Cytokine Mechanisms in Induced Brain Tolerance to Injury / KAORU TASAKI, HIROSHI NAWASHIRO, TOSHIHO OHTSUKI, CHRISTL RUETZLER DAVID MARTIN, and JOHN M. HALLENBECK* -- chapter 19 Kinins and CNS Injury and Inflammation: Effect of the Bradykinin B2 Antagonist, CP-0597, in Animal Models of Stroke / JANE K. RELTON, VIRGINIA E. BECKEY and ERIC T. WHALLEY * -- chapter 20 DNA Damage and Repair: An Alternative Mechanism of Cell Death after Cerebral Ischemia / CHUNG Y. HSU -- chapter Selectins, ICAMs, and Integrins in CNS Injury / GREGORY J. DEL ZOPPO* -- chapter 22 Chemokines in Central Nervous System Inflammation / RICHARD M. RANSOHOFF -- chapter The Expression and Function of Cell Adhesion Molecules in Neurodegenerative Disease / KIERAN C. BREEN -- chapter 24 Cytokines in Acute Brain Injury and Stroke / NANCY ROTHWELL -- chapter Inflammation-Mediated Neuronal Cell Injury / CHUN C. CHAO -- chapter 26 Neurogenomics and the Discovery of Novel Inflammatory Mediators in the Central Nervous System / GREGORY S. KELNER, RICHARD MAKI, and ERROL B. DE SOUZA*.
Summary This book looks at the causes and long-term effects of inflammation in the CNS as a result of various conditions, and the therapeutic opportunities presented in each case. Each chapter is written by an acknowledged leader in the field.
Note Print version record.
ISBN 0203304241 (electronic bk.)
9780203304242 (electronic bk.)
OCLC # 53947747
Additional Format Print version: Inflammatory cells and mediators in CNS diseases. Amsterdam : Harwood Academic Publishers, ©1999 9057022966 (OCoLC)41646911