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LEADER 00000cam  2200829Ii 4500 
001    822997165 
003    OCoLC 
005    20181101045405.8 
006    m     o  d         
007    cr cnu---unuuu 
008    121228s2013    nyu     ob    101 0 eng d 
010    2012951339 
015    GBB2A7421|2bnb 
019    823722434|a858888560|a957524226|a957599515|a985058209
       |a1005801088|a1026449577 
020    9781461447566|q(electronic bk.) 
020    1461447569|q(electronic bk.) 
020    9781461447559|q(print) 
020    1461447550|q(print) 
020    |z9781461447599 
024 7  10.1007/978-1-4614-4756-6|2doi 
035    (OCoLC)822997165|z(OCoLC)823722434|z(OCoLC)858888560
       |z(OCoLC)957524226|z(OCoLC)957599515|z(OCoLC)985058209
       |z(OCoLC)1005801088|z(OCoLC)1026449577 
037    1461447550|b00024965 
040    GW5XE|beng|epn|erda|cGW5XE|dYDXCP|dN$T|dCOO|dOHS|dZMC
       |dIDEBK|dE7B|dOCLCF|dVVL|dVT2|dOCLCO|dEBLCP|dDEBSZ|dOCLCO
       |dOCL|dOCLCO|dOCLCQ|dOCLCO|dOCLCQ|dOCLCO|dOCLCQ|dESU
       |dOCLCQ|dOCLCO|dNJR|dOCLCA|dREB|dIOG|dOCLCO|dCEF|dU3W
       |dOCLCO 
049    MAIN 
050  4 QP535.N2|bI58 2011 
060  4 QU 34 
072  7 SCI|x017000|2bisacsh 
072  7 QP|2lcco 
082 04 571.6/4|223 
111 2  International Conference on Sodium-Calcium Exchange|n(6th 
       :|d2011 :|cLacco Ameno, Italy)|0http://id.loc.gov/
       authorities/names/n2016183566 
245 10 Sodium calcium exchange: A growing spectrum of 
       pathophysiological implications :|bproceedings of the 6th 
       International Conference on Sodium Calcium Exchange /
       |cLucio Annunziato, editor. 
264  1 New York :|bSpringer,|c2013. 
300    1 online resource. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc|0http://rdaregistry.info/termList/
       RDAColourContent/1003 
347    text file|2rdaft|0http://rdaregistry.info/termList/
       fileType/1002 
490 1  Advances in experimental medicine and biology,|x0065-2598 
       ;|v961 
500    International conference proceedings. 
500    Includes indexes. 
504    Includes bibliographical references and indexes. 
505 00 |tHISTORICAL PERSPECTIVE --|tLivin' with NCX and Lovin' It
       : A 45 Year Romance --|t20 Years from NCX Purification and
       Cloning: Milestones --|tSTRUCTURAL AND FUNCTIONAL ASPECTS 
       OF NCX --|tCa2+ Regulation in the Na+/Ca2+ Exchanger 
       Features a Dual Electrostatic Switch Mechanism --
       |tMolecular Determinants of Allosteric Regulation in NCX 
       Proteins --|tNCX1: Mechanism of Transport --|tStructural 
       Studies of the Ca2+ Regulatory Domain of Drosophila Na+/
       Ca2+ Exchanger CALX --|tInterplay of Ca2+ and Mg2+ in 
       Sodium-Calcium Exchanger and in Other Ca2+-Binding 
       Proteins: Magnesium, Watchdog That Blocks Each Turn if 
       Able --|tSTRUCTURAL AND FUNCTIONAL ASPECTS OF NCKX --
       |tFunctional and Structural Properties of the NCKX2 Na+-
       Ca2+/K+ Exchanger: A Comparison with the NCX1 Na+/Ca2+ 
       Exchanger --|tNCKX5, a Natural Regulator of Human Skin 
       Colour Variation, Regulates the Expression of Key Pigment 
       Genes MC1R and Alpha-MSH and Alters Cholesterol 
       Homeostasis in Normal Human Melanocytes. 
505 80 |tExpression and Regulation of Sodium/Calcium Exchangers, 
       NCX and NCKX, in Reproductive Tissues: Do They Play a 
       Critical Role in Calcium Transport for Reproduction and 
       Development? --|tGENETIC AND EPIGENETIC REGULATION --
       |tTranscriptional Pathways and Potential Therapeutic 
       Targets in the Regulation of Ncx1 Expression in Cardiac 
       Hypertrophy and Failure --|tTranscriptional Regulation of 
       ncx1 Gene in the Brain --|tREGULATORY MECHANISMS OF NCX --
       |tMetabolic Regulation of the Squid Nerve Na+/Ca2+ 
       Exchanger: Recent Developments --|tRegulation of Sodium-
       Calcium Exchanger Activity by Creatine Kinase --
       |tCoordinated Regulation of Cardiac Na+/Ca2+ Exchanger and
       Na+-K+-ATPase by Phospholemman (FXYD1) --|tSUBCELLULAR 
       LOCALIZATION AND FUNCTION OF NCX IN Ca2+-STORING 
       ORGANELLES AND MITOCHONDRIA --|tMitochondria Na+-Ca2+ 
       Exchange in Cardiomyocytes and Lymphocytes --|tNew 
       Insights in Mitochondrial Calcium Handling by Sodium/
       Calcium Exchanger --|tNCX IN NEURODEGENERATIVE DISEASES --
       |tGenetically Modified Mice as a Strategy to Unravel the 
       Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia 
       and in Spatial Learning and Memory Deficits. 
505 80 |tNCX as a Key Player in the Neuroprotection Exerted by 
       Ischemic Preconditioning and Postconditioning --|tThe Role
       of the Mitochondrial NCX in the Mechanism of 
       Neurodegeneration in Parkinson's Disease --|tNCX IN 
       NEURODEGENERATIVE DISEASES --|tThe Contribution of the 
       Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca2+ 
       ATPase (PMCA) to Cerebellar Synapse Function --|tEMERGING 
       ROLE OF NCX ACTIVITY IN IMMUNE AND GLIAL CELLS --|tSodium-
       Calcium Exchanger Modulates the L-Glutamate Cai 2+ 
       Signalling in Type-1 Cerebellar Astrocytes --
       |tImmunosuppressive Drugs, Immunophilins, and Functional 
       Expression of NCX Isoforms --|tCalcium Influx Through 
       Reversed NCX Controls Migration of Microglia --|tSodium 
       Fluxes and Astroglial Function --|tNew Roles of NCX in 
       Glial Cells: Activation of Microglia in Ischemia and 
       Differentiation of Oligodendrocytes --|tHuman Macrophages 
       and Monocytes Express Functional Na+/Ca2+ Exchangers 1 and
       3 --|tNCX IN THE HEART AND VASCULAR SMOOTH MUSCLE --|tNew 
       Insights into the Contribution of Arterial NCX to the 
       Regulation of Myogenic Tone and Blood Pressure. 
520    This book reports the text of the lectures of the 6th 
       International Conference on Sodium Calcium Exchange held 
       in Lacco Ameno in the Island of Ischia in the Gulf of 
       Naples, Italy, from October 1 to October 5, 2011. The 
       present book uncovers the most striking new findings on 
       NCX that emerged since the previous Conference on Sodium 
       Calcium Exchange, such as the structural dissection of the
       molecular determinants of Ca2+ sensitivity of the 
       exchanger, the epigenetic regulation of ncx1 gene, the 
       molecular identification of the mitochondrial Sodium 
       Calcium Exchanger, and the discovery of NCX in unexpected 
       anatomical locations such as the female reproductive 
       tract. The book is organized into 11 parts covering NCX 
       structural aspects, genetic and epigenetic regulation, 
       regulatory mechanisms, subcellular localization in 
       mitochondria, involvement in neurodegenerative diseases 
       and in immune regulation, and the role of the 
       cardiovascular and endocrine systems, as well as diabetes 
       in physiology and pathophysiology. Selected chapters of 
       the book are also devoted to the interaction of NCKX and 
       other ion channels and transporters with NCX, like ASICs, 
       TRPM, and NHE. Lucio Annunziato is Professor of 
       Pharmacology and chairman of the Department of 
       Neuroscience in the School of Medicine at the "Federico 
       II" University of Naples, Italy. He is coordinator of the 
       University's Neuroscience Ph. D. program. He is also past-
       president of the Italian Society for Neuroscience. Dr. 
       Annunziato has authored more that 190 full papers in peer 
       reviewed international journals in the field of 
       neuroscience and molecular pharmacology of plasmamembrane 
       transporters and ionic channels involved in the 
       pathophysiology of stroke and other neurodegenerative 
       diseases. 
650  0 Sodium cotransport systems|0http://id.loc.gov/authorities/
       subjects/sh90002687|vCongresses.|0http://id.loc.gov/
       authorities/subjects/sh99001533 
650  0 Sodium channels|0http://id.loc.gov/authorities/subjects/
       sh86007510|vCongresses.|0http://id.loc.gov/authorities/
       subjects/sh99001533 
650  0 Calcium channels|vCongresses.|0http://id.loc.gov/
       authorities/subjects/sh2009118146 
650  2 Biological Transport.|0https://id.nlm.nih.gov/mesh/D001692
650  2 Calcium Channels.|0https://id.nlm.nih.gov/mesh/D015220 
650  2 Sodium Channels.|0https://id.nlm.nih.gov/mesh/D015222 
653  4 Medicine. 
653  4 Immunology. 
653  4 Neurosciences. 
653  4 Cardiology. 
653  4 Endocrinology. 
653  4 Biomedicine. 
655  0 Electronic books. 
655  2 Congress.|0https://id.nlm.nih.gov/mesh/D016423 
655  4 Electronic books. 
655  7 Conference papers and proceedings.|2fast|0http://
       id.worldcat.org/fast/1423772 
655  7 Conference papers and proceedings.|2lcgft|0http://
       id.loc.gov/authorities/genreForms/gf2014026068 
700 1  Annunziato, Lucio.|0http://id.loc.gov/authorities/names/
       nb2010001046 
776 08 |iPrinted edition:|z9781461447559 
830  0 Advances in experimental medicine and biology ;|0http://
       id.loc.gov/authorities/names/n42001229|v961. 
880 80 |6505-00/(S|tToward an Understanding of the Complete NCX1 
       Lifetime in the Cardiac Sarcolemma --|tNCX ROLE IN 
       HYPERTENSION, HEART FAILURE, ISCHEMIA-REPERFUSION, 
       ARRHYTHMIAS AND DIABETES --|tCardiac Sodium-Calcium 
       Exchange and Efficient Excitation-Contraction Coupling: 
       Implications for Heart Disease --|tCross Talk Between 
       Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/Orai-
       Containing Channels: Key Players in Arterial Hypertension 
       --|tT-Tubule Remodelling and Ryanodine Receptor 
       Organization Modulate Sodium-Calcium Exchange --|tNa+/Ca2+
       Exchange and the Plasma Membrane Ca2+-ATPase in β-Cell 
       Function and Diabetes --|tNCX PARTNERS IN IONIC 
       HOMEOSTASIS: ASIC, NMDA, NHE AND TRPC --|tThe Na+/H+ 
       Exchanger NHE5 Is Sorted to Discrete Intracellular 
       Vesicles in the Central and Peripheral Nervous Systems --
       |tThe Role of Na+/H+ Exchanger Isoform 1 in Inflammatory 
       Responses: Maintaining H+ Homeostasis of Immune Cells --
       |tAcid-Sensing Ion Channels in Pathological Conditions --
       |tNonselective Cation Channels and Links to Hippocampal 
       Ischemia, Aging, and Dementia. 
990    SpringerLink|bSpringer English/International eBooks 2013 -
       Full Set|c2018-10-31|yNew collection 
       springerlink.ebooks2013|5OH1 
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