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Title Prions and diseases. Volume 2, Animals, humans and the environment / Wen-Quan Zou, Pierluigi Gambetti, editors.
Imprint New York ; London : Springer, 2013.

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Subject Prions.
Prion diseases -- Pathogenesis.
Prions -- pathology.
Prions -- genetics.
Alt Name Zou, Wen-Quan.
Gambetti, Pierluigi.
Add Title Animals, humans and the environment
Description 1 online resource
polychrome rdacc
Contents Bovine Spongiform Encephalopathy / Gianluigi Zanusso and Salvatore Monaco -- Classical and Atypical Scrapie in Sheep and Goats / Christine Fast and Martin H. Groschup -- Chronic Wasting Disease and the Development of Research Models / Glenn Telling -- Human Sporadic Prion Diseases / Pierluigi Gambetti and Silvio Notari -- Environmentally Acquired Transmissible Spongiform Encephalopathy / Paul Brown -- Prions in the Environment / Shannon L. Bartelt-Hunt, Jason C. Bartz and Samuel E. Saunders -- The Spectrum of Tau Pathology in Human Prion Disease / Gabor G. Kovacs and Herbert Budka -- Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion / Alexander H. Peden, Mark W. Head and James W. Ironside -- Species Barriers in Prion Disease / Suzette A. Priola -- Transgenic Mice Modelling / Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford and Matthew Bishop, et al. -- Transgenic Mouse Models in Prion Transmission Studies / Qingzhong Kong -- Alternative Models of Prion Diseases / Pedro Fernandez-Funez, Edward Malaga-Trillo and Diego E. Rincon-Limas -- Diagnosis of Prion Disease: Conventional Approaches / Inga Zerr, Joanna Gawinecka, Katharina Stoeck and Maren Breithaupt -- Quaking-Induced Conversion Assays for the Detection and Diagnosis of Prion Diseases / Jason M. Wilham, Christina D. Orru, Sarah Vascellari, Andrew G. Hughson and Byron Caughey -- The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context / T. Dean Airey and Neil R. Cashman -- Overview on Treatment of Prion Diseases and Decontamination of Prions / Richard Knight -- Immunomodulation / Thomas Wisniewski and Fernando Goni.
Bibliography Note Includes bibliographical references and index.
Summary Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases. Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
Note Print version record.
ISBN 9781461453383 (electronic bk.)
1461453380 (electronic bk.)
ISBN/ISSN 10.1007/978-1-4614-5338-3
OCLC # 819587653
Additional Format Print version: Prions and diseases. Volume 2, Animals, humans and the environment. New York ; London : Springer, 2012 9781461453376 (OCoLC)817270716

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