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Title Prions and diseases. Volume 1, Physiology and pathophysiology / edited by Wen-Quan Zou and Pierluigi Gambetti.
Imprint New York ; London : Springer, 2013.

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Series Prions and diseases ; 1
Subject Prions.
Prion diseases -- Pathophysiology.
Prion Diseases -- pathology.
Prions.
Alt Name Zou, Wen-Quan.
Gambetti, Pierluigi.
Add Title Physiology and pathophysiology
Description 1 online resource.
polychrome rdacc
Contents Transmissible Spongiform Encephalopathy: From its Beginnings to Daniel Carlton Gajdusek / Paul Brown -- The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein / Glenn L. Millhauser -- Role of Cellular Prion Protein in the Amyloid-[beta] Oligomer Pathophysiology of Alzheimer's Disease / Adam C. Kaufman, Stephen M. Strittmatter -- Cellular Prion Protein and Cancers / Wei Xin, Man-sun Sy, Chaoyang Li -- Insoluble Cellular Prion Protein / Wen-Quan Zou -- Protein Misfolding Cyclic Amplification / Fabio Moda, Sandra Pritzkow, Claudio Soto -- Cofactor Involvement in Prion Propagation / Surachai Supattapone, Michael B. Miller -- Prion Protein Conversion and Lipids / Jiyan Ma -- New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating / Ilia V. Baskakov -- Infectious and Pathogenic Forms of PrP / Emiliano Biasini, David A. Harris -- Cellular Mechanisms of Propagation and Clearance / Hermann M. Schatzl -- Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains / Jiri G. Safar -- Modeling the Cell Biology of Prions / Richard Rubenstein, Robert B. Petersen -- Prion Strain Interference / Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz -- Introduction to Yeast and Fungal Prions / Reed B. Wickner -- Yeast Prions Are Pathogenic, In-Register Parallel Amyloids / Reed B. Wickner, Herman K. Edskes, David A. Bateman.
Summary Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases. Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Note Print version record.
ISBN 9781461453055 (electronic bk.)
1461453054 (electronic bk.)
9781461453048
1461453046
ISBN/ISSN 10.1007/978-1-4614-5305-5
OCLC # 820952410
Additional Format Print version: Physiology and pathophysiology. New York ; London : Springer, 2012 9781461453048 (OCoLC)817270688


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