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Title The role of microtubules in cell biology, neurobiology, and oncology / edited by Tito Fojo.
Imprint Totowa, N.J. : Humana Press, 2008.

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Series Cancer drug discovery and development.
Cancer drug discovery and development.
Subject Microtubules.
Cancer -- Chemotherapy.
Neoplasms -- drug therapy.
Cell Biology.
Alt Name Fojo, Antonio Tito, 1952-
Description 1 online resource (xviii, 587 pages, 38 unnumbered pages of plates) : illustrations, portrait.
Bibliography Note Includes bibliographical references and index.
Note Print version record.
Contents An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly -- Molecular Mechanisms of Microtubule Acting Cancer Drugs -- Microtubule Dynamics -- Microtubule-Associated Proteins and Microtubule-Interacting Proteins -- The Post-Translational Modifications of Tubulin -- The Isotypes of Tubulin -- The Tubulin Superfamily -- Tubulin Proteomics in Cancer -- Tubulin and Microtubule Structures -- Destabilizing Agents -- Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin -- Antimicrotubule Agents That Bind Covalently to Tubulin -- Microtubule Stabilizing Agents -- Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly -- Resistance to Microtubule-Targeting Drugs -- Microtubule Stabilizing Agents in Clinical Oncology -- Investigational Anticancer Agents Targeting the Microtubule -- Microtubule Damaging Agents and Apoptosis -- Microtubule Targeting Agents and the Tumor Vasculature -- Neurodegenerative Diseases -- Structure, Function, and Regulation of the Microtubule Associated Protein Tau.
Summary The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases. Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.
ISBN 9781597453363
1588292940 (Cloth)
OCLC # 314357381
Additional Format Print version: Role of microtubules in cell biology, neurobiology, and oncology. Totowa, N.J. : Humana Press, 2008 9781588292940 1588292940 (DLC) 2008920860 (OCoLC)248345191.

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